Visitors to Nuevo Progreso and other destinations of the border will not be able to buy liquor, beer or wine this weekend.
Mexican authorities are applying the "dry law" for Sunday's presidential elections.
Under Mexican law, alcohol cannot be sold in the 24 hours before the election and cannot be sold on election day.
As a result, no alcohol will be sold in Mexico on Saturday or Sunday.
Stores, restaurants and bars in Nuevo Progreso, Matamoros, Reynosa and the rest of Mexico will stop selling at midnight Friday.
The law applies equally for Mexican citizens and foreign tourists.
The sale of alcohol will resume in Mexico after on Monday.
The dry law does not apply to UETA, Baja or other duty free stores on the Texas side of the border.
Mexico TMs La Ley Seca or Dry Law dates back to after the Mexican Revolution and prohibits the sale of alcohol during major elections.