The University of Texas at Brownsville will begin operating as its own entity under the University of Texas system this fall.
Student enrollment is expected to drop by 40 percent meaning that less faculty and staff will be needed.
In addition to that, the UTB and Texas Southmost College's partnership recently came to an end after 20 years.
News of this transition came two years ago and is scheduled to go into effect this fall, at the beginning of the 2013-2014 school year.
According to UTB officials, only about 60 percent of the current student enrollment will be considered as UTB students come this fall.
Administrators said that resizing staff and faculty positions is necessary.
Some 88 faculty members were notified in December that their position would likely be terminated as a result of the split.
But UTB officials said another 250 staff positions are also now likely to be cut.
The university vice president and department heads reviewed the positions.
They TMll make their cut recommendations to UTB President Dr. Juliet V. Garcia on Tuesday.
Although the announcement will be made on Tuesday, the job cuts will not go into effect until August 31st.