Police were able to confiscate a truck and 600 pounds of marijuana on Tuesday, but were unable to catch the suspected drug smugglers.
The group of smugglers led police on a high speed chase from La Joya to La Grulla.
The pursuit ended when the men ran their truck into the Rio Grande River, according to police.
Police said the men fled from the vehicle and went into the river with some of the marijuana bundles.
Rafts were waiting by the river TMs edge for the smugglers.
All the men were able to cross back into Mexico.